期刊
INTERNATIONAL JOURNAL OF CARDIOLOGY
卷 228, 期 -, 页码 280-285出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2016.11.017
关键词
Sudden cardiac death; Implantable cardioverter defibrillator; Lead; Device-related complications
资金
- British Heart Foundation [FS/14/9/30407] Funding Source: researchfish
Background: Subcutaneous implantable cardioverter defibrillators (S-ICD) have become more widely available. However, comparisons with conventional transvenous ICDs (TV-ICD) are scarce. Methods: We conducted a propensity matched case-control study including all patients that underwent S-ICD implantation over a five-year period in a single tertiary centre. Controls consisted of all TV-ICD implant patients over a contemporary time period excluding those with pacing indication, biventricular pacemakers and those with sustained monomorphic ventricular tachycardia requiring anti-tachycardia pacing. Data was collected on device-related complications and mortality rates. A cost efficacy analysis was performed. Results: Sixty-nine S-ICD caseswere propensity matched to 69 TV-ICD controls. During a mean follow-up of 31 +/- 19 (S-ICD) and 32 +/- 21 months (TV-ICD; p = 0.88) there was a higher rate of device-related complications in the TV-ICD group predominantly accounted for by lead failures (n = 20, 29% vs. n = 6, 9%; p = 0.004). The total mean cost for each group, including the complication-related costs was 9967 pound +/- 4511 ($13,639 +/- 6173) and 12,601 pound +/- 1786 ($17,243 +/- 2444) in the TV-ICD and S-ICD groups respectively (p = 0.0001). Even though more expensive S-ICD was associated with a relative risk reduction of device-related complication of 70% with a HR of 0.30 (95% CI 0.12-0.76; p = 0.01) compared to TV-ICDs. Conclusions: TV-ICDs are associated with increased device-related complication rates compared to a propensity matched S-ICD group during a similar follow-up period. Despite the existing significant difference in unit cost of the S-ICD, overall S-ICD costs may be mitigated versus TV-ICDs over a longer follow-up period. (C) 2016 Published by Elsevier Ireland Ltd.
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