期刊
SCIENCE
卷 369, 期 6506, 页码 936-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aax0701
关键词
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资金
- RHU Torino Lumiere [ANR-16-RHUS-0008]
- Seerave Foundation
- Ligue contre le Cancer (equipe labelisee)
- Agence Nationale de la Recherche (ANR)
- ANR Francogermanique under the frame of E-Rare-2, the ERA-Net for Research on Rare Diseases [ANR-19-CE150029]
- Association pour la recherche sur le cancer (ARC)
- Canceropole Ile-de-France
- Fondation pour la Recherche Medicale (FRM)
- European Research Council (ERC)
- High-end Foreign Expert Program in China, Institut National du Cancer (INCa) [GDW20171100085, GDW20181100051]
- Inserm (HTE)
- Institut Universitaire de France
- LeDucq Foundation
- LabEx Immuno-Oncology
- SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE)
- CARE network
- SIRIC Cancer Research and Personalized Medicine (CARPEM)
- National Research, Development and Innovation Fund of Hungary Project [FIEK_16-1-2016-0005]
- Research and Technology Innovation Fund [NAP2-2017-1.2.1-NKP-0002]
- Breast Cancer Research Foundation [BCRF-17-156]
- Novo Nordisk Foundation Interdisciplinary Synergy Programme Grant [NNF15OC0016584]
- Italian Association for Cancer Research [AIRC IG 19822]
- TRiPoD ERC-Advanced EU [322856]
- European Research Council [ERC-STG MetaPG-716575]
- Institut Pasteur (Paris, France)
- ONCOBIOME H2020 network
- Fondation Carrefour
Intestinal microbiota have been proposed to induce commensal-specific memory T cells that cross-react with tumor-associated antigens. We identified major histocompatibility complex (MHC) class I-binding epitopes in the tail length tape measure protein (TMP) of a prophage found in the genome of the bacteriophage Enterococcus hirae. Mice bearing E. hirae harboring this prophage mounted a TMP-specific H-2K(b)-restricted CD8(+) T lymphocyte response upon immunotherapy with cyclophosphamide or anti-PD-1 antibodies. Administration of bacterial strains engineered to express the TMP epitope improved immunotherapy in mice. In renal and lung cancer patients, the presence of the enterococcal prophage in stools and expression of a TMP-cross-reactive antigen by tumors correlated with long-term benefit of PD-1 blockade therapy. In melanoma patients, T cell clones recognizing naturally processed cancer antigens that are cross-reactive with microbial peptides were detected.
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