期刊
INTERNATIONAL JOURNAL OF CANCER
卷 141, 期 4, 页码 646-653出版社
WILEY
DOI: 10.1002/ijc.30708
关键词
melanoma; nanomedicine; nanocarrier; photothermal therapy; photodynamic therapy; RNA interference; targeting
类别
资金
- National Natural Science Foundation of China [81372916]
- Science and Technology Department of Jiangsu Province [BK20141142]
- Jiangsu Provincial Medical Talent Foundation
Melanoma is a most aggressive skin cancer with limited therapeutic options and its incidence is increasing rapidly in recent years. The discovery and application of new targeted therapy agents have shown significant benefits. However, adverse side-effects and resistance to chemotherapy remain formidable challenges in the clinical treatment of malignant melanoma. Nanotherapeutics offers an important prospect of overcoming these drawbacks. The anti-tumoral applications of nanomedicine are varied, including those in chemotherapy, RNA interference, photothermal therapy, and photodynamic therapy. Furthermore, nanomedicine allows delivery of the effector structures into the tumor site via passive or active targeting, thereby allowing increased therapeutic specificity and reduced side effects. In this review, we summarize the latest developments in the application of nanocarrier-mediated targeted drug delivery to melanoma and nanomedicine-related clinical trials in melanoma treatment. We also discuss existing problems and opportunities for future developments, providing direction and new thoughts for further studies.
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