期刊
JOR SPINE
卷 3, 期 4, 页码 -出版社
WILEY
DOI: 10.1002/jsp2.1117
关键词
annulus fibrosus; bioink; biomaterials; endplate; extracellular matrix; MSCs; nucleus pulposus; stem cells
类别
Intervertebral disc (IVD) degeneration is a major cause of low back pain and represents a massive socioeconomic burden. Current conservative and surgical treatments fail to restore native tissue architecture and functionality. Tissue engineering strategies, especially those based on 3D bioprinting and electrospinning, have emerged as possible alternatives by producing cell-seeded scaffolds that replicate the structure of the IVD extracellular matrix. In this review, we provide an overview of recent advancements and limitations of 3D bioprinting and electrospinning for the treatment of IVD degeneration, focusing on future areas of research that may contribute to their clinical translation.
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