期刊
INTERNATIONAL JOURNAL OF CANCER
卷 141, 期 8, 页码 1561-1565出版社
WILEY
DOI: 10.1002/ijc.30866
关键词
cervical cancer; HIV in women; cancer prevention
类别
资金
- UAB-MS WIHS [U01-AI-103401]
- Atlanta WIHS [U01-AI-103408]
- Bronx WIHS [U01-AI-035004]
- Brooklyn WIHS [U01-AI-031834]
- Chicago WIHS [U01-AI-034993]
- Metropolitan Washington WIHS [U01-AI-034994]
- Miami WIHS [U01-AI-103397]
- UNC WIHS [U01-AI-103390]
- Connie Wofsy Women's HIV Study, Northern California [U01-AI-034989]
- WIHS Data Management and Analysis Center [U01-AI-042590]
- Southern California WIHS [U01-HD-032632, UL1-TR000004, UL1-TR000454]
- National Institute of Allergy and Infectious Diseases (NIAID)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Cancer Institute (NCI)
- National Institute on Drug Abuse (NIDA)
- National Institute on Mental Health (NIMH)
- National Institute of Dental and Craniofacial Research (NIDCR)
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- National Institute on Deafness and other Communication Disorders (NIDCD)
- NIH Office of Research on Women's Health
To estimate the incidence of invasive cervical cancer (ICC) across up to 21 years of follow-up among women with human immunodeficiency virus (HIV) and to compare it to that among HIV-uninfected women, we reviewed ICC diagnoses from a 20-year multi-site U.S. cohort study of HIV infected and uninfected women who had Pap testing every 6 months. Incidence rates were calculated and compared to those in HIV-negative women. Incidence ratios standardized to age-, sex-, race-, and calendar-year specific population rates were calculated. After a median follow-up of 12.3 years, four ICCs were confirmed in HIV seropositive women, only one in the last 10 years of observation, and none in seronegative women. The ICC incidence rate did not differ significantly by HIV status (HIV seronegative: 0/100,000 person-years vs. HIV seropositive: 19.5/100,000 person-years; p=0.53). The standardized incidence ratio for the HIV-infected WIHS participants was 3.31 (95% CI: 0.90, 8.47; p=0.07). Although marginally more common in women without HIV, for those with HIV in a prevention program, ICC does not emerge as a major threat as women age.
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