期刊
INTERNATIONAL JOURNAL OF CANCER
卷 142, 期 4, 页码 813-821出版社
WILEY
DOI: 10.1002/ijc.31099
关键词
tumor-infiltrating tryptase plus mast cells; unfavorable outcome; solid tumor; meta-analysis
类别
资金
- National Natural Science Foundation of China [81702803]
The prognostic role of tumor-infiltrating tryptase(+) mast cells in human solid tumors remains controversial. Herein, we conducted a meta-analysis including 28 published studies with 4224 patients identified from PubMed and EBSCO to assess the prognostic impact of tumor-infiltrating tryptase(+) mast cells in human solid tumors. We found that tryptase(+) mast cell infiltration significantly decreased overall survival (OS) and disease-free survival (DFS) in all types of solid tumors. In stratified analyses, tryptase(+) mast cell infiltration was significantly associated with worse OS in non-small cell lung cancer, hepatocellular carcinoma and 5-year survival in colorectal cancer. And these cells were inversely associated with DFS in hepatocellular and colorectal cancer. In addition, high density of intratumoral tryptase(+) mast cells significantly correlated with lymph node metastasis of solid tumor. In conclusion, Tryptase(+) mast cell infiltration leads to an unfavorable clinical outcome in solid tumors, implicating that it is a valuable biomarker for prognostic prediction for human solid malignances and targeting it may have a potential for effective treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据