期刊
BIOMATERIALS SCIENCE
卷 8, 期 15, 页码 4266-4274出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0bm00706d
关键词
-
资金
- Northwest AF University [Z111021601]
- [A279021724]
Bacterial infection has been recognized as one of the greatest threats to public health. In view of the continuous increase of bacterial resistance, constructing a collaborative bactericidal platform is a promising strategy to enhance the efficiency of antimicrobial agents. Herein, we report a facile, biocompatible and versatile nano-platform based on positively charged copper manganate nanoflakes (CuMnO(2)NFs), which exhibits intrinsic peroxidase-like catalytic activity and excellent photothermal properties. The CuMnO(2)NFs can bind with negatively charged bacteriaviaelectrostatic interactions, and generate hydroxyl radicals (center dot OH) through catalysis involving hydrogen peroxide (H2O2) to make bacteria more susceptible to temperature. Introducing near-infrared light generates hyperthermia to fight against bacteria and enhances the peroxidase-like catalytic activity of the CuMnO(2)NFs, thus producing more center dot OH to combat bacteria. The PTT-enhanced center dot OH synergistic antibacterial strategy exerts desirable antibacterial efficiencies of 98.78% and 99.92% againstEscherichia coli(E. coli) andStaphylococcus aureus(S. aureus) at a controlled low temperature (below 50 degrees C), without damage to healthy tissues. Animal experiments indicate that this synergistic treatment has a better therapeutic effect onS. aureus-infected wounds in mice, compared with either treatment by itself. Therefore, this work holds great promise for developing new synergistic antimicrobial strategies to treat bacterial infections.
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