期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 101, 期 -, 页码 630-637出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2017.03.148
关键词
Hydroxyapatite; Beta-tricalcium phosphate; Platelet-rich plasma; Bone healing and regeneration; Radius
This study compared the regeneration potentials of the hydroxyapatite (HA) and beta-tricalcium phosphate ((3-TCP) alone or in combination with a HA:TCP ratio of 30:70 in the critical-sized radial bone defects of rats. Bilateral 60 radial bone defects created were randomly divided into six equal groups (n = 10 defects/group) including autograft, untreated or defect, chitosan-gelatin-platelet gel (CGP), CGPHA, CGP-TCP and CGP-HA/TCP. The defects were evaluated by radiography, morphology, histopathology, histomorphometry, CT scan, scanning electron microscopy and biomechanical testing after eight weeks. Compared with the untreated and CGP-HA groups, the CGP and CGP-HA/TCP groups showed significantly higher new bone formation, bone volume, and mechanical properties. The CGP-HA and CGP-TCP scaffolds showed low biodegradability, whereas the CGP scaffolds were completely degraded. Osteoconductivity and osteoinductivity of the CGP and CGP-HA/TCP scaffolds were superior to the CGP-HA ones. The untreated and CGP-HA groups repaired mostly through fibrosis, while there were evidence of higher bone formation in the autograft, CGP and CGP-HA/TCP groups. In conclusion, addition of HA or S-TCP alone into the CGP scaffolds impaired bone regeneration, while bone regeneration with the CGP and CGP-HA/TCP scaffolds was comparable with the autograft. Therefore, the CGP-HA/TCP scaffold can be a possible option to substitute the autologous bone grafting. (C) 2017 Elsevier B.V. All rights reserved.
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