期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 102, 期 -, 页码 741-748出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2017.04.091
关键词
Pilose antler peptide; Middle cerebral artery occlusion; Nrf-2/HO-1/NF-kappa B
The purpose of the current study was to detect the effect of pilose antler peptide (PAP) on cerebral ischemia and explore its potential mechanism. Middle cerebral artery occlusion (MCAO) was performed to investigate the effects of PAP on cerebral ischemia. The rats were randomly divided into five groups: sham group, model(I/R) group, I/R+ Clopidogrel group, I/R+ PAP (50 mg/kg) group, I/R+ PAP (100 mg/kg) group. The results showed that PAP significantly reduced brain infarct size, inhibited cerebral edema, decreased th eneurological deficits. Treatment with PA reduced the contents of malondialdehyde(MDA) and restore the activity of superoxide dismutase(SOD) in serum and brains. Lig also could effectively decrease the levels of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in serum and brain tissues of the MCAO rats. Western blot results demonstrated that PAP up-regulated the expressions of Nrf-2 and HO-1, also blocked the phosphorylations of I kappa B kinases(IKK)alpha, IKK beta, inhibitor of NF-kappa B(I kappa B)alpha, nuclear factor kappa B(NF-kappa B) p65 in I/R-induced brains. Our findings suggested that PAP effectively attenuated the I/R-induced cerebral ischemia through Nrf-2/HO-1/NF-kappa B pathway. (C) 2017 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据