期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 98, 期 -, 页码 595-609出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2017.01.134
关键词
Ca2+-dependent; Catalytic attributes; In silico analysis; Micronutrients; Monogastric; Nutrition; Phytase; Phytic acid; Plant growth promotion; Probiotics; beta-Propeller phytases
资金
- Department of Biotechnology, Govt. of India [BT/AGR/BIOFORTI/PHII/NIN/2011]
- Ministry of Food Processing Industries (MoFPI), Govt. of India [No.5-11/2010-HRD]
Phytases are phosphatases which stepwise remove phosphates from phytic acid or its salts. -Propeller phytase (BPPhy) belongs to a special class of microbial phytases that is regarded as most diverse, isolated and characterized from different microbes, mainly from Bacillus spp. BPPhy class is unique for its Ca2+-dependent catalytic activity, strict substrate specificity, active at neutral to alkaline pH and high thermostability. Numerous sequence and structure based studies have revealed unique attributes and catalytic properties of this class, as compared to other classes of phytases. Recent studies including cloning and expression and genetic engineering approaches have led to improvements in BPPhy which provide an opportunity for extended utilization of this class of phytases in improving animal nutrition, human health, plant growth promotion, and environmental protection, etc. This review describes the sources and diversity of BPPhy genes, biochemical properties, Ca2+ dependence, current developments in structural elucidation, heterogeneous expression and catalytic improvements, and multifarious applications of BPPhy. (C) 2017 Elsevier B.V. All rights reserved.
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