期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 105, 期 -, 页码 204-212出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2017.07.026
关键词
Anti-complementary activity; Immunological activity; jujube lignin
资金
- Foundation of Fuli Institute of Food Science, Zhejiang University [KY201404]
Two homogenous biological macromolecules, designated as JJC1 and JJC2 were extracted from Zizyphus jujube cv. Jinchangzao. Their molecular weights were determined to be 56.03 and 112.11 kDa by high performance gel permeation chromatography (HPGPC), respectively. Chemical and spectral analysis indicated that both JJC1 and JJC2 mainly consisted of lignin, along with carbohydrates (similar to 18%). Both JJC1 and JJC2 could stimulate the proliferation of spleen lymphocytes, and enhance phagocytosis and NO production of RAW264.7 cells. In addition, JJC2, but not JJC1 elicited an inhibitory effect on complement activation through the classical pathway (CH50: 2.73 mg/mL) as well as the alternative pathway (AP(50): 2.99 mg/mL). These findings implied that water-soluble lignins were one of the bioactive components in Z. jujube, and further provided insights into the understanding of molecular basis for diverse medicinal and nutritional values of this fruit. (C) 2017 Elsevier B.V. All rights reserved.
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