期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 104, 期 -, 页码 1158-1164出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2017.07.029
关键词
Anti-inflammation; Antioxidative effects; Lung-protective effects; Oudemansiella radicata; Selenium polysaccharides
资金
- Mushroom Technology System of Shandong Province [SDAIT-07-05]
- Fundamental Research Funds for Central Non-profit Scientific Institution [1610132016041]
The present work was designed to investigated the antioxidant, anti-inflammation, and pulmonary protective effects of SMPS and MPS from Oudemansiella radicata on LPS-induced lung injured mice. The results demonstrated that SMPS showed potential effects on relieving lung injury and preventing oxidative stress, reflecting by decreasing the serum levels of C3, CRP and GGT, increasing the pulmonary activities of SOD, GSH-Px, CAT and T-AOC, as well as down-regulating the MDA and LPO contents, respectively. Furthermore, the levels of TNF-alpha. (224.211 +/- 3.12 ng/mL), IL-1 beta (254.557 +/- 2.18 ng/L), and IL-6 (18.214 +/- 0.15 ng/L) in BALF of mice treated with SMPS at the dosage of 400 mg/kg/d significantly lower than that in the lung injured mice. These conclusions indicated that both SMPS and MPS possessed potent antioxidants and anti-inflammation activities, and could be used as functional foods and natural drugs in preventing lung injury. (C) 2017 Elsevier B.V. All rights reserved.
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