期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 104, 期 -, 页码 708-715出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2017.06.044
关键词
Surface modification; Chitosan; Poly(epsilon-caprolactone) fiber; Cell proliferation; Antibacterial activity
资金
- National Natural Science Foundation of China [51303060]
The surface modification is one of the most effective methods to improve the bioactivity and cell affinity effect of electrospun poly(epsilon-caprolactone) (PCL) fibers. In the present study, chitosan (CS), a cationic polysaccharide, was used to modify the surface of electrospun PCL fibers. To obtain strong interaction between CS and PCL fibers, negatively charged PCL fibers were prepared by the incorporation of acid treated carbon nanotubes (CNTs) into the fibers. In this way, the positively charged chitosan could be immobilized onto the surface of PCL fibers tightly by the electrostatic attraction. Besides, the incorporation of CNTs could significantly improve the mechanical strength of electrospun PCL fibers even after the CS modification, which guaranteed their usability in practical applications. The CS modification could effectively improve the wettability and bioactivity of electrospun PCL fibers. Cultivation of L929 fibroblast cells on the obtained fibers and the antibacterial activity were both evaluated to discuss the influence of chitosan modification. The results indicated that this modification could enhance the cell proliferation and antibacterial ability in comparison to the non -modified groups. (C) 2017 Elsevier B.V. All rights reserved.
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