期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 105, 期 -, 页码 741-748出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2017.07.094
关键词
Antimicrobial peptides; Cellulose nanofibers; Cellulose nanopapers; Alkyl ketene dimer
资金
- Spanish Ministry of Economy and Competitiveness [CTQ2013-48090-C2-2-R]
In this work we report the production of cellulose nanopapers modified with alkyl ketene dimer (AKD) in order to allow the immobilization of antimicrobial peptides (AMPS) to produce surfaces with antimicrobial properties. Cellulose nanofibers (CNF) were prepared from softwood bleached pulp via high pressure homogenization after chemical pretreatment of fibers via TEMPO oxidation. Nanopapers were then prepared after a casting technique and functionalized with alkyl ketene dimer before AMPs were immobilized. The immobilization process was performed by submerging the samples into AMP aqueous solutions and then dried at room temperature. Antimicrobial activity was tested against B. subtilis. Results indicated that AMPs were bound onto the nanopaper surface and released when the nanopaper was put in contact with the culture medium, which effectively demonstrates the viability of the immobilization process. (C) 2017 Elsevier B.V. All rights reserved.
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