期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 95, 期 -, 页码 132-137出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2016.11.051
关键词
Acute kidney injury; Low-molecular-weight sulfated polysaccharide; Renal protective effect
资金
- Natural Science Foundation of China (NSFC) [41376166]
- Special Fund for Marine Scientific Research in Huangdao District [2014-04-11]
- Youth Innovation Promotion Association of CAS [2016190]
- Scientific and Technological Innovation Project - Qingdao National Laboratory for Marine Science and Technology [2015ASKJ02]
- Shandong Province Science & Technology Development Project [2014GHY115017]
- Science and Technology program of applied basic research projects of Qingdao Municipal [15-9-1-74-jch]
We investigated the renal protective effect of low-molecular-weight sulfated polysaccharide (LMWSP) fractions extracted from Laminaria japonica on glycerol-induced acute kidney injury (AKI) in rats. Glycerol treatment significantly increased serum creatinine (SCr) and blood urea nitrogen (BUN) levels. Intraperitoneal injection of LMWSP fractions markedly decreased SCr and BUN levels and reduced renal swelling. The fraction of 1.0 M NaCl displayed the best renal protective effect of all fractions in attenuating AKI and maintaining blood glucose. (C) 2016 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据
分享论文
