期刊
LABEL-FREE BIOMEDICAL IMAGING AND SENSING (LBIS) 2020
卷 11251, 期 -, 页码 -出版社
SPIE-INT SOC OPTICAL ENGINEERING
DOI: 10.1117/12.2547179
关键词
Raman spectroscopy; microscopy; imaging; dynamics; biomedical; coherent Raman spectroscopy
资金
- National Science Foundation (NSF) [DBI-1455671, ECCS-1509268, CMMI-1826078]
- Air Force Office of Scientific Research (AFOSR) [FA9550-15-1-0517, FA9550-18-1-0141]
- Defense Advanced Research Projects Agency (DARPA) [FA8650-13-D-6368/0006]
- Army Research Laboratory (ARL) [W911NF-17-2-0144]
- Office of Naval Research (ONR) [N00014-16-1-2578]
- National Institutes of Health (NIH) [1R01GM127696-01]
- Cancer Prevention and Research Institute of Texas (CPRIT) [RP180588]
- National Natural Science Foundation of China [11934011]
- Zhejiang University start-up fund
Coherent Raman microspectroscopy utilizing either stimulated Raman scattering or coherent Raman scattering is gaining popularity in the field of biological imaging. It is generally assumed that coherent Raman spectroscopy provides a stronger signal than conventional spectroscopy based on spontaneous scattering, allowing much faster imaging. In this report we examine non-trivial advantages of coherent Raman microspectroscopy, which haven't been given significant attention lately. In particular, we demonstrate the potential of improving sensitivity of Raman spectroscopy and ability to sense the local nanoenvironment.
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