期刊
RESPIRATORY MEDICINE CASE REPORTS
卷 30, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.rmcr.2020.101131
关键词
Drug-induced pneumonitis; Diffuse alveolar hemorrhage; Immune checkpoint inhibitor; Immunotherapy; Cancer
资金
- National Institutes of Health through MD Anderson's Cancer Center Support Grant [CA016672]
We describe a 60 year old man who developed respiratory insufficiency after treatment with 2 rounds of nivolumab monotherapy. Imaging revealed subtle ground glass infiltrates which progressed to diffuse opacities and consolidation. The patient was treated with high dose corticosteroids, empiric antimicrobial therapy and infliximab. Bronchoscopy with lavage revealed negative cultures and progressive bloody aliquots of fluid consistent with diffuse alveolar hemorrhage. The patient succumbed to respiratory failure. An autopsy study confirmed extensive alveolar hemorrhage. Our reports highlights clinical and diagnostic findings with immunotherapy-induced pneumonitis.
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