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Gold-catalyzed enantioselective functionalization of indoles

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ORGANIC & BIOMOLECULAR CHEMISTRY
卷 18, 期 31, 页码 6006-6017

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ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ob01245a

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  1. MESRI (Paris-Saclay University)
  2. CHARMMMAT Laboratory of Excellence [ANR-11-LABX0039]

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Gold catalysis and indole chemistry are two mature and prolific fields. The gold-catalyzed functionalization of indoles has produced numerous results and paved the way for novel strategies in the building of molecular complexity. However - and curiously - though enantioselective gold catalysis is now a well-established field, it has been relatively little applied to the modification of indoles. This review highlights most of the enantioselective gold-catalyzed examples of the functionalization of indoles in order to emphasize the strengths and limitations of the method.

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