期刊
ORGANIC CHEMISTRY FRONTIERS
卷 7, 期 16, 页码 2187-2195出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0qo00561d
关键词
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资金
- MIUR PRIN 2017 project 2017YJMPZN
The interest in DNA based nanostructures arises from their potential applications in diagnostics and drug delivery and in the development of new hybrid and conducting materials. Guanine-rich oligonucleotides can multimerize forming long and stable supramolecular structures, known as G-wires, based on the G-quadruplex (G4) motif. Herein, we report a method to easily obtain long DNA G-wires based on a new tetramolecular G4 subunit formed by the d(5 '-CGG-3 '-3 '-GGC-5 ') sequence containing a 3 '-3 ' inversion of polarity site. The formation of the G-wire assembly exploits the multimerization ability of G4s presenting the CGG motif at their 5 ' endvia pi-pi stacking interactions between flanking G4 subunits. The structures and the stability of the resulting G-wires were investigated by HPLC, size exclusion chromatography, polyacrylamide gel electrophoresis, circular dichroism,H-1 NMR and atomic force microscopy studies.
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