期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 8, 期 31, 页码 7009-7017出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0tb00817f
关键词
-
资金
- Natural Science Foundation of China (NNSFC) [51690150, 51690154, 51722307, 51673179, 51773190]
- Fundamental Research Funds for the Central Universities [WK3450000003]
The emerging therapeutic potential of nitric oxide (NO) has spurred the rapid development of NO donors to maximize the therapeutic outcomes. Although polymeric NO donors have shown extended release times and optimized biodistributions, many of these macromolecular NO donors are non-degradable. Herein, we devise a macromolecular NO donor by integrating photoresponsiveN,N '-dinitroso-p-phenylenediamine (DNP) derivatives into the middle block of an amphiphilic triblock copolymer and the photo-mediated NO release process transforms the DNP to quinondimine (QDI) moieties, enabling the degradation of the resulting polymers due to the spontaneous hydrolysis of QDI moieties. We demonstrated that the NO release process could be selectively activated under visible light irradiation bothin vitroandin vivo. Moreover, the simultaneous release of NO and DOX could be achieved under visible light by taking advantage of the NO release-mediated micelle disassembly. This work provides new insights into the design of degradable macromolecular NO donors where the polymer breakdown could be actuated by triggered NO release.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据