期刊
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
卷 49, 期 2, 页码 137-152出版社
ELSEVIER
DOI: 10.1016/j.ijantimicag.2016.11.011
关键词
Antibiotic resistance; Antimicrobial agents; Mechanism of action; Metal oxide; Micro-organisms; Nanotoxicity
资金
- University Grants Commission-Basic Scientific Research Fellowship (UGC-BSR) [F7-25/2007]
- University Grants Commission-Special Assistance Programme [UGC-SAP-II] [F-3-20/2013]
- Department of Science and Technology
- Improvement of Science and Technology Infrastructure in Universities and Higher Education Institutions [DSTFIST] (New Delhi, India) [SR/FST/LSI-618/2014]
Microbial infectious diseases are a global threat to human health. Excess and improper use of antibiotics has created antimicrobial-resistant microbes that can defy clinical treatment. The hunt for safe and alternate antimicrobial agents is on in order to overcome such resistant micro-organisms, and the birth of nanotechnology offers promise to combat infectious organisms. Over the past two decades, metal oxide nanoparticles (MeO-NPs) have become an attractive alternative source to combat microbes that are highly resistant to various classes of antibiotics. Their vast array of physicochemical properties enables MeO-NPs to act as antimicrobial agents through various mechanisms. Apart from exhibiting antimicrobial properties, MeO-NPs also serve as carriers of drugs, thus barely providing a chance for microorganisms to develop resistance. These immense multiple properties exhibited by MeO-NPs will have an impact on the treatment of deadly infectious diseases. This review discusses the mechanisms of action of MeO-NPs against micro-organisms, safety concerns, challenges and future perspectives. (C) 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.
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