期刊
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
卷 49, 期 5, 页码 526-535出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijantimicag.2016.11.029
关键词
Enterobacteriaceae; Pseudomonas aeruginosa; Acinetobacter baumannii; Colistin resistance; MCR-1; Two-components systems
资金
- French Ministry of Health through the agency Sante publique France
Polymyxins have recently been re-introduced into the therapeutic arsenal to combat infections caused by multidrug-resistant Gram-negative bacteria. However, the emergence of strains resistant to these last-resort drugs is becoming a critical issue in a growing number of countries. Both intrinsic and transferable mechanisms of polymyxin resistance have been characterised. These mechanisms as well as the epidemiological data regarding four relevant bacterial pathogens (Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa) are considered in this review. A special focus is made on plasmid-mediated resistance and the spread of mcr genes. (C) 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.
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