期刊
NEURAL REGENERATION RESEARCH
卷 15, 期 9, 页码 1590-1600出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/1673-5374.276326
关键词
Alzheimer's disease; biomarkers; diffusional kurtosis imaging; disease progression; early diagnosis; free-water imaging; neurites; neurite orientation dispersion and density imaging; Parkinson's disease
资金
- Japan Agency for Medical Research and Development (AMED) [JP18dm0307024]
- MEXT
- ImPACT Program of Council for Science, Technology and Innovation (Cabinet Office, Government of Japan)
- JSPS KAKENHI [JP16K10327]
The prevalence of neurodegenerative diseases is increasing as human longevity increases. The objective bio-markers that enable the staging and early diagnosis of neurodegenerative diseases are eagerly anticipated. It has recently become possible to determine pathological changes in the brain without autopsy with the advancement of diffusion magnetic resonance imaging techniques. Diffusion magnetic resonance imaging is a robust tool used to evaluate brain microstructural complexity and integrity, axonal order, density, and myelination via the micron-scale displacement of water molecules diffusing in tissues. Diffusion tensor imaging, a type of diffusion magnetic resonance imaging technique is widely utilized in clinical and research settings; however, it has several limitations. To overcome these limitations, cutting-edge diffusion magnetic resonance imaging techniques, such as diffusional kurtosis imaging, neurite orientation dispersion and density imaging, and free water imaging, have been recently proposed and applied to evaluate the pathology of neurodegenerative diseases. This review focused on the main applications, findings, and future directions of advanced diffusion magnetic resonance imaging techniques in patients with Alzheimer's and Parkinson's diseases, the first and second most common neurodegenerative diseases, respectively.
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