期刊
SYNTHETIC AND SYSTEMS BIOTECHNOLOGY
卷 5, 期 3, 页码 179-186出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.synbio.2020.06.005
关键词
Isoprenoids; Yeast; Compartmentalization; Sub-organelle metabolism
资金
- National Natural Science Foundation of China [21877111, 21922812]
- China Postdoctoral Science Foundation [199936]
Current yeast metabolic engineering in isoprenoids production mainly focuses on rewiring of cytosolic metabolic pathway. However, the precursors, cofactors and the enzymes are distributed in various sub-cellular compartments, which may hamper isoprenoid biosynthesis. On the other side, pathway compartmentalization provides several advantages for improving metabolic flux toward target products. We here summarize the recent advances on harnessing sub-organelle for isoprenoids biosynthesis in yeast, and analyze the knowledge about the localization of enzymes, cofactors and metabolites for guiding the rewiring of the sub-organelle metabolism. This review may provide some insights for constructing efficient yeast cell factories for production of isoprenoids and even other natural products.
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