Smart magnetic nanopowder based on the manganite perovskite for local hyperthermia

For many medical applications related to diagnosis and treatment of cancer disease, hyperthermia plays an increasingly important role as a local heating method, where precise control of temperature and parameters of the working material is strongly required. Obtaining a smart material with self-controlled heating in a desirable temperature range is a relevant task. For this purpose, the nanopowder of manganite perovskite with super-stoichiometric manganese has been synthesized, which consists of soft spherical-like ferromagnetic nanoparticles with an average size of 65 nm and with a narrow temperature range of the magnetic phase transition at 42 degrees C. Based on the analysis of experimental magnetic data, a specific loss power has been calculated for both quasi-stable and relaxation hysteresis regions. It has been shown that the local heating of the cell structures to 42 degrees C may occur for a short time (similar to 1.5 min.) Upon reaching 42 degrees C, the heating is stopped due to transition of the nanopowder to the paramagnetic state. The obtained results demonstrate the possibility of using synthesized nanopowder as a smart magnetic nanomaterial for local hyperthermia with automatic heating stabilization in the safe range of hyperthermia without the risk of mechanical damage to cell structures.