4.5 Article

Identification of EmSOX2, a member of the Sox family of transcription factors, as a potential regulator of Echinococcus multilocularis germinative cells

期刊

INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 47, 期 10-11, 页码 625-632

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2017.03.005

关键词

Echinococcus multilocularis; Germinative cells; SOX2; Proliferation

资金

  1. National Natural Science Foundation of China [81000740, 81171596, 81471970, 81501764, 81572018]
  2. Fundamental Research Funds for the Central Universities of People's Republic of China [2012121044]

向作者/读者索取更多资源

Larvae of the tapeworm Echinococcus multilocularis cause alveolar echinococcosis (AE), one of the most lethal helminthic infections in humans. The germinative cells, a population of stem cell-like cells, are considered to drive the continuous growth of the metacestodes within the host. The mechanisms and relative molecules controlling the behavior of germinative cells are poorly understood. Sox transcription factors play important roles in maintenance and regulation of stem/progenitor cells. We here describe the identification of a Sox family member in E. multilocularis, EmSOX2, as a potential regulator of germinative cells. Replacement of mouse Sox2 with EmSox2 could derive induced pluripotent stem cells (iPSCs) from somatic cells, suggesting that EmSOX2 is functionally related to mammalian SOX2. EmSOX2 is actively expressed in the proliferating germinative cells in E. multilocularis, and is significantly downregulated upon specific depletion of the germinative cell population by hydroxyurea treatment. These findings suggest that EmSOX2 may play a critical role in regulating E. multilocularis germinative cells. (C) 2017 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据