期刊
CHEMICAL ENGINEERING JOURNAL
卷 399, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2020.125797
关键词
Platinum-carbon nanozyme; Photodynamic-catalytic therapy; ROS
资金
- National Natural Science Foundation of China [21703198, 21001091, 21922202]
- University Natural Science Foundation of Jiangsu Province [16KJD150004]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Top-notch Academic Programs Project of Jiangsu Higher Education Institutions
Photodynamic therapy (PDT) is an effective approach for tumor treatment, which converts oxygen into reactive oxygen species (ROS) through light irradiation upon a photosensitizer. Due to the low instability of most current photosensitizers, nanocarriers for loading and delivering photosensitizers were specifically needed to be developed. However, most nanocarriers, such as polymer-based, lipid-based vehicles, only act as a carrier, without antitumor activity. Thus, development of suitable nanocarriers for photosensitizers with integrating multi -antitumor functions will improve the efficiency of PDT. Here, we reported two different kinds of Pt/carbon (Pt/C) nanozymes as the nanocarriers for chlorin e6 (Ce6) loading. Besides the PDT based on Ce6, Pt/C nanozymes could mimic the activities of peroxidase and oxidase to transfer H2O2 and O2 in tumor sites to ROS respectively, further killing tumor. By comparing the distribution of Pt nanoparticles inside or outside the carbon spheres, we found that it exhibited higher enzyme-mimicking and antitumor activity when the Pt was loaded outside the carbon shell. Cellular and animal studies demonstrated that the efficient tumor destruction was achieved through the combination of PDT and nanozyme-based catalytic therapy. These results implied that the intrinsic enzyme-like activity of nanozymes and PDT can be synergized for efficient tumor treatment, providing a proof of-concept of tumor photodynamic-catalytic therapy.
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