Promising reagents for difluoroalkylation

This review describes recent advances in difluoroalkylation reactions using different substrates. Generally speaking, RCF(2)radical is generally proposed in the mechanism of these reactions. At present, the most used difluoroalkylation reagent is RCF2X, which can be reduced by metal, photocatalyst or bases to RCF(2)radical. Various substrates such as alkenes, alkynes, amines and so on could well be applied to these difluoroalkylation reactions.