期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 45, 期 -, 页码 148-155出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2017.02.010
关键词
LPS/D-GaIN; Morin; Nrf2; NF-kappa B
资金
- National Natural Science Foundation of China [31572347, 31372478]
Morin, a bioactive flavonoid extracted from the bark of Moraceae plants and many medicinal herbs, has anti-inflammatory and antioxidative effects. In this research, we explored the protective effects of morin against lipopolysaccharide (LPS) and dn-galactosamine (D-GaIN) induced acute liver injury in mice. Mice were given an intraperitoneal injection of morin before LPS and D-GaIN treatment and the HepG2 cells were only given morin to investigate its effects. The results showed that morin markedly inhibited the production of serum alanine transaminase (ALT), aspartate aminotransferase (AST), interleukin-6 (IL-6), tumor necrosis factor (TNF alpha) and hepatic TNF-alpha, IL-6, and myeloperoxidase (MPO) induced by LPS/D-GaIN. In order to evaluate morin effect in the future, we investigated the expression of nuclear factor E2 related factor 2 (Nrf2), nuclear factorkappaB (NF-kappa B), toll like receptor 4 (TLR4) on liver injury. Taken together, these results suggested that morin could exert the anti-inflammatory and anti-oxidative effects against LPS/D-GaIN-induced acute liver injury by activating Nrf2 signal pathways and inhibiting NF-kappa B activation. (C) 2017 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据