期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
卷 1861, 期 11, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbabio.2020.148276
关键词
Mitochondria; Cell energetic metabolism; Thermodynamics; Kinetics; Crabtree effect; Warburg effect; Metabolism modeling
资金
- CNRS (Conseil National de la Recherche Scientifique)
- Comite de Dordogne & Gironde de la Ligue Nationale Contre le Cancer
- Fondation ARC pour la recherche sur le Cancer [BIO 2014 06]
- Plan cancer 2014-2019, ANR [BIO 2014 06]
- European Commission
In living cells, growth is the result of coupling between substrate catabolism and multiple metabolic processes that take place during net biomass formation and maintenance processes. During growth, both ATP/ADP and NADH/NAD(+) molecules play a key role. Cell energy metabolism hence refers to metabolic pathways involved in ATP synthesis linked to NADH turnover. Two main pathways are thus involved in cell energy metabolism: glycolysis/fermentation and oxidative phosphorylation. Glycolysis and mitochondrial oxidative phosphorylation are intertwined through thermodynamic and kinetic constraints that are reviewed herein. Further, our current knowledge of short-term and long term regulation of cell energy metabolism will be reviewed using examples such as the Crabtree and the Warburg effect.
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