期刊
CURRENT HYPERTENSION REPORTS
卷 17, 期 8, 页码 -出版社
SPRINGER
DOI: 10.1007/s11906-015-0575-8
关键词
Preeclampsia; Blood-brain barrier; Pregnancy; Cerebral blood flow; Autoregulation
资金
- National Institutes of Health [R01 NS045940, R01 NS093289, P01 HL095488]
- Preeclampsia Foundation Vision Award
- Cardiovascular Research Institute of Vermont
- Totman Medical Research Trust
Preeclampsia is a hypertensive, multisystem disorder of pregnancy that affects several organ systems, including the maternal brain. Cerebrovascular dysfunction during preeclampsia can lead to cerebral edema, seizures, stroke, and potentially maternal mortality. This review will discuss the effects of preeclampsia on the cerebrovasculature that may adversely affect the maternal brain, including cerebral blood flow (CBF) autoregulation and blood-brain barrier disruption and the resultant clinical outcomes including posterior reversible encephalopathy syndrome (PRES) and maternal stroke. Potential long-term cognitive outcomes of preeclampsia and the role of the cerebrovasculature are also reviewed.
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