期刊
CURRENT HIV RESEARCH
卷 14, 期 1, 页码 61-70出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570162X1401151102143222
关键词
Abacavir; antiretroviral therapy; endothelial dysfunction; inflammation; tenofovir
Background: The association between abacavir use and increased risk of myocardial infarction has been heavily debated, but cohort studies and randomized trials have provided conflicting results. Aim of our study is to compare the effect of abacavir and tenofovir on the inflammation and endothelial activation markers. Methods: We performed an observational study of HIV-infected naive patients starting tenofovir/emtricitabine (group A) or abacavir/lamivudine (group B) plus efavirenz. In the present analysis, we measured serum levels of high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), soluble vascular adhesion molecule-1 (VCAM-1), soluble intercellular adhesion molecule-1 (ICAM-1), E-selectin and P-selectin at baseline and during a 48-week follow-up. Results: As a whole, 118 patients (93 males; mean age +/- SD of 42.8 +/- 10.1 years) were enrolled: 61 in group A and 57 in group B. In group A at weeks 24 and 48 the mean concentrations of IL-6, TNF-alpha, ICAM-1, VCAM-1, E-selectin and P-selectin decreased significantly in comparison with respective baseline values. In group B at week 24 a significant increase in mean values of these markers was reported in comparison with group A, but after 48 weeks they significantly decreased in group B too and no significant differences between groups A and B were found. Conclusion: In our study, naive patients starting tenofovir/emtricitabine or abacavir/lamivudine plus efavirenz showed after 48 weeks a significant and comparable decrease in serum concentrations of IL-6, TNF-alpha, ICAM-1, VCAM-1, E-selectin and P-selectin, while the mean level of hs-CRP did not change significantly in any group.
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