4.3 Article

Urolithiasis is prevalent and associated with reduced bone mineral density in β-thalassaemia major

期刊

INTERNAL MEDICINE JOURNAL
卷 47, 期 9, 页码 1064-1067

出版社

WILEY
DOI: 10.1111/imj.13533

关键词

computed tomography; kidney stone; osteoporosis; thalassaemia; urolithiasis

资金

  1. Australian Postgraduate Scholarship
  2. Royal Australasian College of Physicians and Osteoporosis Australia Scholarship
  3. National Health and Medical Research Council (Australia) CJ Martin Early Career Fellowship
  4. Haematology Society of Australia
  5. Haematology Society of New Zealand
  6. National Health and Medical Research Council (Australia) Senior Principal Research Fellowship [1002559]
  7. Victorian Government's Operational Infrastructure Support program

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Asymptomatic urolithiasis is common and of mixed composition in patients with beta-thalassaemia major. Twenty-seven subjects were imaged using dual-energy computer tomography to determine the presence and composition of urolithiasis. The prevalence of urolithiasis was 59% and affected patients generally had multiple stones, often with more than one component: struvite (33%), calcium oxalate (31%) and cystine (22%). Hypercalciuria was present in 78% of subjects and calcium-containing urolithiasis was associated with reduced femoral neck Z scores.

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