期刊
RSC ADVANCES
卷 10, 期 50, 页码 29829-29834出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ra06322c
关键词
-
资金
- Spanish Government (MCIU/AEI/FEDER, UE) [CTQ2017-84779-R]
- Generalitat de Catalunya [2017 DI 072]
- University of Barcelona
We describe a novel transition metal-free method for the synthesis ofN-difluoromethylated pyridines and 4-pyridones/quinolones by using readily available ethyl bromodifluoroacetate as a fluorine source. The formation ofN-difluoromethylated pyridines involves a two-step process in whichN-alkylation by ethyl bromodifluoroacetate is followed byin situhydrolysis of the ester and decarboxylation. Besides optimizing theN-difluoromethylation conditions and assessing the influence of steric and electronic effects on the outcome of the reaction, we have synthesized theN-difluoromethylated analogues of two fluorophores and demonstrated that their spectroscopic properties can be improved through replacement ofN-CH(3)group byN-CF2H.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据