期刊
CANCER BIOLOGY & MEDICINE
卷 17, 期 3, 页码 569-582出版社
CHINA ANTI-CANCER ASSOC
DOI: 10.20892/j.issn.2095-3941.2020.0033
关键词
Biomarker; cancer; chemoresistance; epithelial-mesenchymal transition; miR-135a; therapeutics
资金
- National Natural Science Foundation of China [81772639, 81802475, 81972258, 81974376]
- Natural Science Foundation of Beijing [7192157]
- CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-I2M-1-001]
- China Postdoctoral Science Foundation [198831]
- National Key R&D Program of China [2018YFE0118600]
MicroRNAs (miRNAs) are evolutionarily conserved small non coding RNAs that affect posttranscriptional regulation by binding to the 3'- untranslated region of target messenger RNAs. MiR-135a is a critical miRNA that regulates gene expression, and many studies have focused on its function in cancer research. MiR-135a is dysregulated in various cancers and regulates cancer cell proliferation and invasion via several signaling pathways, such as the MAPK and JAK2/STAT3 pathways. MiR-135a has also been found to promote or inhibit the epithelial-mesenchymal transition and chemoresistance in different cancers. Several studies have discovered the value of miR-135a as a novel biomarker for cancer diagnosis and prognosis. These studies have suggested the potential of therapeutically manipulating miR-135a to improve the outcome of cancer patients. Although these findings have demonstrated the role of miR-135a in cancer progression and clinical applications, a number of questions remain to be answered, such as the dual functional roles of miR-135a in cancer. In this review, we summarize the available studies regarding miR-135a and cancer, including background on the biogenesis and expression of miR-135a in cancer and relevant signaling pathways involved in miR-135a-mediated tumor progression. We also focus on the clinical application of miR-135a as a biomarker in diagnosis and as a therapeutic agent or target in cancer treatment, which will provide a greater level of insight into the translational value of miR-135a.
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