期刊
INORGANICA CHIMICA ACTA
卷 455, 期 -, 页码 283-297出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ica.2016.10.035
关键词
S-allyl dithiocarbazate; Ni(II), Cu(II) and Zn(II) complexes; Single crystal study; Biomolecular interaction; Catalytic activity
资金
- NSF-MRI program [CHE-1039027]
A new series of bivalent Ni(II), Cu(II) and Zn(II) metal complexes containing Schiff base ligand [H-emksadtc] [(E)-ally! 2-(butan-2-ylidene) hydrazine carbodithioate)] were synthesized and characterized by different spectroscopic techniques. The molecular structure of the ligand and its complexes 1 [(E)-allyl 2-(butan-2-ylidene) hydrazine carbodithioato nickel(II)], complex 2 [(E)-allyl 2-(butan-2-ylidene) hydrazine carbodithioato copper(II)1, complex 3 [(E)-ally! 2-(butan-2-ylidene) hydrazine carbodithioato zinc (II)] were confirmed by single crystal X-ray crystallography. XRD data of the complexes had revealed a distorted square planar geometry around the metal ion, satisfied by N2S2 fashion. Density functional calculations of all the compounds in gas phase were performed by using DFT (B3LYP) with 6-311G basis set. The calculated FT-IR and structural data are in good agreement with the experimental results and confirmed by the experimental one. The interactions of calf thymus (CT) DNA and bovine serum albumin (BSA) with complexes 1-3 were explored by emission spectra. Catecholase and phosphatase-like activities of all the complexes were also investigated. An in vitro cytotoxicity study of the complexes had shown significant activity against human cervical cancer cell line (HeLa) with the best results of complex 2, which was found to be more toxic to cancer cells with a few micromolar concentrations, as the IC50 value, but significantly less toxic to normal cell lines. Additionally, the cell death analysis was carried out by AO/EB and DAPI staining methods. (C) 2016 Elsevier B.V. All rights reserved.
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