期刊
INORGANIC CHEMISTRY
卷 56, 期 17, 页码 10474-10480出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.inorgchem.7b01475
关键词
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资金
- Spanish Ministry of Economy and Competitivity
- UE Feder Program (CRM Juan de la Cierva Contract)
- University of Granada (CRM Reincorporacion Plan Propio)
- Junta de Andalucia [P09-FQM-4981]
- COST action [CM1105]
- UE Feder Program [CTQ2014-53486R]
Mesoporous silica Al-MCM-41 nanoparticles have been used, for the first time, as vehicles for the single and dual encapsulation of the cationic CO-releasing molecule (CORM) [Mn(1,4,7,triazacyclononane)(CO)(3)](+) (ALF472(+)) and the well-known antineoplastic drug, cis-[PtCL2(NH3)(2)] (cisplatin). Thus, two new hybrid materials, namely, ALF472@Al-MCM-41 and ALF472-cisplatin@Al-MCM-41, have been isolated and fully characterized. The results reveal that the presence of CORM molecules enhances cisplatin loading 3 fold, yielding a cargo of 0.45 mmol g(-1) of ALF472(+) and 0.12 mmol g(-1) of the platinum complex for ALF472-cisplatin@Al-MCM-41. It is worth noting that ALF472@A1-MCM-41 shows a good dispersion in phosphate buffered saline solution, while the dual hybrid material slightly aggregates in this simulated physiological medium (hydrodynamic size: 112 +/- 23 and 336 +/- 50 nm, respectively). In addition, both hybrid materials (ALF472@Al-MCM-41 and ALF472-cisplatin@Al-MCM-41) behave as photoactive CO-releasing materials, delivering 0.25 and 0.11 equiv of CO, respectively, after 24 h and exhibiting a more controlled CO delivery than that of the free CORM. Finally, metal leaching studies have confirmed the good retention capacity of Al-MCM-41 toward the potentially toxic manganese fragments (86% of retention after 72 h) as well as the low release of cisplatin (ca. 7% after 72 h).
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