期刊
INORGANIC CHEMISTRY
卷 57, 期 2, 页码 681-688出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.inorgchem.7b02533
关键词
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资金
- National Institutes of Health [NHLBI UH2 L123610, NIGMS RO1 GM081030]
- UICentre for Drug Discovery, University of Illinois at Chicago, Office of the Vice Chancellor for Research
Hydrogen sulfide (H2S) is now recognized as an important gaseous transmitter that is involved in a variety of biological processes. Here, we report the design and synthesis of a luminescent lanthanide biosensor for H2S, LP2-Cu(II)-Ln(III), a heterobinudear metal complex that uses Cu(II) decomplexation to control milli-second-scale-lifetime-Tb(III)- or Eu(III)-emission intensity. LP2-Cu(II)-Ln(III) responded rapidly, selectively, and with high sensitivity to aqueous H2S. The probe's potential for biological applications was verified by measuring the H2S generated by the slow releasing chemical-sulfide-donor GYY4147, by cystathionine gamma-lyase (CSE), and by Na2S-stimulated HeLa cells.
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