期刊
INNATE IMMUNITY
卷 23, 期 4, 页码 392-400出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1753425917699864
关键词
LPS; NLRP3 inflammasome; particulate matter; TLR2; TLR4
资金
- Secretariat of the Environment of the Municipality of the Quito Metropolitan District
- Universidad Tecnologica Equinoccial
Automobile traffic, industrial processes and natural phenomena cause notable air pollution, including gaseous and particulate contaminants, in urban centers. Exposure to particulate matter (PM) air pollution affects human health, and has been linked to respiratory, cardiovascular and neurological diseases. The mechanisms underlying inflammation in these diverse diseases, and to what extent health effects are different for PM obtained from different sources or locations, are still unclear. This study investigated the invitro toxicity of ambient course (PM10) and fine (PM2.5) particulate matter collected at seven sites in the urban and periurban zones of Quito, Ecuador. Material from all sites was capable of activating TLR2 and TLR4 signaling pathways, with differences in the activation related to particle size. Additionally, airborne particulate matter from Quito is an effective activator of the NLRP3 inflammasome.
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