期刊
CARBOHYDRATE POLYMERS
卷 247, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.116685
关键词
ZnO; Palygorskite; Chitooligosaccharides; Nanocomposites; Antibacterial activities
资金
- Major Projects of the Natural Science Foundation of Gansu, China [18JR4RA001]
- Funds for Creative Research Groups of Gansu, China [17JR5RA306]
- Major Projects of Science and Technology of Jiangsu, China [BE2019071]
- Regional Key Project of the Science and Technology Service of the Chinese Academy of Sciences [KFJ-STS-QYZX-086]
Quaternary ammonium chitooligosaccharides (QACOS) was incorporated onto the ZnO/palygorskite (ZnO/PAL) nanocomposite by a simple electrostatic self-assembly process to produce a new organic-inorganic nanocomposite (QACOS/ZnO/PAL) with excellent antibacterial activity. After loading QACOS, the Zeta potential of ZnO/PAL was changed from -26.7 to + 30.3 mV, which facilitates to improve the targeting behavior of ZnO/PAL towards bacteria and its contact with bacteria, resulting in a significant improvement of antibacterial capability. The MIC values of QACOS/ZnO/PAL for inhibiting bacteria (0.5 mg/mL for E. coil and 1 mg/L for S. aureus) were superior to ZnO/PAL and QACOS, demonstrated an expected synergistic antibacterial effect between QACOS and ZnO/PAL. The improved contact and interface interaction between QACOS/ZnO/PAL and bacteria makes it easier to destroy the structural integrity of bacteria. As a whole, the incorporation of polysaccharide as regulators of surface charge opens up a new way to further enhance the antibacterial activity of inorganic antibacterial materials.
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