期刊
BIOMATERIALS SCIENCE
卷 8, 期 18, 页码 4887-4905出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0bm00390e
关键词
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资金
- ERC Starting Grant INTERCELLMED [759959]
- My First AIRC Grant (MFAG-2019) [22902]
- FISR-C.N.R.
- Tecnopolo di Nanotecnologia e Fotonica per la medicina di precisione [B83B17000010001]
- Tecnopolo per la medicina di precisione - Regione Puglia [B84I18000540002]
- European Research Council (ERC) [759959] Funding Source: European Research Council (ERC)
Electrospinning is historically related to tissue engineering due to its ability to produce nano-/microscale fibrous materials with mechanical and functional properties that are extremely similar to those of the extracellular matrix of living tissues. The general interest in electrospun fibrous matrices has recently expanded to cancer research both as scaffolds for in vitro cancer modelling and as patches for in vivo therapeutic delivery. In this review, we examine electrospinning by providing a brief description of the process and overview of most materials used in this process, discussing the effect of changing the process parameters on fiber conformations and assemblies. Then, we describe two different applications of electrospinning in service of cancer research: firstly, as three-dimensional (3D) fibrous materials for generating in vitro pre-clinical cancer models; and secondly, as patches encapsulating anticancer agents for in vivo delivery.
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