期刊
CANCER BIOLOGY & MEDICINE
卷 17, 期 3, 页码 528-542出版社
CHINA ANTI-CANCER ASSOC
DOI: 10.20892/j.issn.2095-3941.2020.0032
关键词
CMTM family; cancer; cell cycle; EGFR; EMT; apoptosis; tumor immunity
资金
- National Natural Science Foundation of China [81670123, 81670144]
- Wuhan University Medical Faculty Innovation Seed Fund Cultivation Project [TFZZ2018025]
The CKLF-like MARVEL transmembrane domain containing (CMTM) family of genes comprises CKLF and CMTM1-8 (previously called chemokine-like factor superfamily 1-8, CKLFSF1-8). The CMTM family proteins contain a structurally conserved MAL and related proteins for vesicle trafficking and membrane linking (MARVEL) domain. Dysregulated expression of multiple CMTM family members is a common feature in many human cancer types. CMTM proteins control critical biological processes in cancer development, including growth factor receptor activation and recycling, cell proliferation, apoptosis, metastasis, and immune evasion. Emerging in vivo and in vitro evidence indicates that the mechanisms of action of most CMTM proteins are complex and multifactorial. This review highlights new findings regarding the roles of CMTM1-8 in cancer, particularly in tumor growth, metastasis, and immune evasion. Additionally, the potential clinical value of CMTMs as novel drug targets or biomarkers is discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据