期刊
ADVANCED THERAPEUTICS
卷 3, 期 9, 页码 -出版社
WILEY
DOI: 10.1002/adtp.202000001
关键词
hydrogels; magnetothermally responsive drug delivery; stem cells; wound healing
资金
- National Natural Science Foundation of China [11627803]
- National Key R&D Program of China [2018YFC0115500, 2018YFE0194500]
- USTC Research Funds of Double FirstClass Initiative [YD2380002001]
Multifunctional dressings are attracting increased interest in the area of tissue engineering and regenerative medicine. Wound healing is a dynamic and complex process that requires multidisciplinary management. However, dressings that exhibit both anti-infective and tissue regenerative properties are still limited. Herein, a hydrogel-based multifunctional dressing weaved by drug-loaded magnetothermally responsive [Fe3O4@SiO2-interpenetrating polymer network (IPN)] microfibers and human umbilical cord mesenchymal stem cell-laden microfibers is developed. Magnetothermally responsive microfibers, as smart constructs, can release antibiotics on-demand to prevent infection, due to the magnetothermal heating effect of the embedded magnetic nanoparticles and the thermoresponsive property of the IPN hydrogels. Furthermore, stem cell-laden microfibers markedly promote cell proliferation and tissue remodeling, with improved re-epithelization, granulation tissue formation, and collagen deposition at the wound site. Hydrogel-based microfibers have the additional ability of absorbing exudate, providing a moist environment, and retaining the therapeutic cells. Therefore, functional microfibers and textiles significantly accelerate the healing process. An advanced dressing for wound healing, incorporating controlled drug delivery and stem cell-based therapy is developed. Furthermore, the results of the present study reveal the potential of multifunctional dressings in tissue engineering and regenerative medicine.
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