期刊
PHYSIOLOGICAL REPORTS
卷 8, 期 16, 页码 -出版社
WILEY
DOI: 10.14814/phy2.14549
关键词
autoregulation index; cerebral hemodynamics; squat-stand maneuvers; transcranial Doppler ultrasound; transfer function analysis
类别
资金
- EPSRC [EP/K041207/1] Funding Source: UKRI
Repeated squat-stand maneuvers (SSM) are an effective way of measuring dynamic cerebral autoregulation (dCA), but the depth of SSM required to improve dCA estimations has never been studied. We compared beat-to-beat cerebral hemodynamic parameters between maximal depth SSM (SSMD) and a shallower alternative (SSMS) in two age groups (younger [20-34 years] vs. older [50-71 years]) at a frequency of 0.05 Hz. Cerebral blood flow velocity, continuous blood pressure (BP) and end-tidal CO2 (EtCO2) were measured using transcranial Doppler ultrasound, the Finometer device, and capnography, respectively. Coherence (at 0.05 Hz) was significantly higher in both SSM recordings compared to spontaneous BP oscillations at baseline standing (B-S). Median (IQR) autoregulation index (ARI) was reduced during SSMD (4.46 [4.03-5.22], p < .01) compared to SSM (S) (5.96 [5.40-6.69]) and B-S(6.03 [5.20-6.49],p < .01) with similar relative differences also observed for phase (at 0.05 Hz). End-tidal CO2 was increased in SSMD (38.3 +/- 3.7 mmHg, p < .01) compared to both SSMS (36.6 +/- 3.6 mmHg) and B-S(35.5 +/- 3.2 mmHg). The older group demonstrated significantly lower ARI and phase estimates during SSM and found SSMS more effortful than SSMD. In conclusion, both SSMD and SSM(S)are effective at estimating dCA, and dCA appears to be less efficient during maximal depth SSM compared to baseline rest or a shallower alternative.
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