期刊
CHEMICAL COMMUNICATIONS
卷 56, 期 72, 页码 10489-10492出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc04831c
关键词
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资金
- National Natural Science Foundation of China [21571143]
- Shandong Provincial Natural Science Foundation of China [ZR2017MB029, ZR2017BB060]
- Qingdao Science and Technology Foundation [18-2-2-49-jch]
A base-mediated cascade amidination/N-alkylation reaction of amines by alcohols has been developed. For the first time, nitriles have been identified as an efficient and benign water acceptor reagent inN-alkylation. Notably, the procedure tolerates a series of functional groups, such as methoxyl, halo, vinyl and hetero groups, providing a convenient method to construct different substituted diamino compounds,N-15 labeled amine and could be scaled up to 1 mol scale offering 138.7 g of the desired product in good yield in one-pot. Mechanistic studies provided strong evidence for the amidination of amines with nitriles facilitated byt-BuOK.
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