期刊
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
卷 10, 期 4, 页码 317-330出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s40097-020-00352-y
关键词
Sargassum muticum; Gold nanoparticles; Silver nanoparticles; Antibacterial activity; Antioxidant activity
资金
- Xunta de Galicia [ED431C 2017/46-GRC, ED431C 2018/54-GRC]
The present work reports on the antibacterial and antioxidant activity of gold and silver nanoparticles, synthesized by an extract of the brown macroalgaSargassum muticum(SM). These nanoparticles were synthesized and fully characterized by means of UV-Vis spectroscopy and electron microscopy. These techniques confirmed that spherical nanoparticles, with mean diameters of 10.4 +/- 1.2 nm for Au@SM and 41.0 +/- 5.7 nm for Ag@SM, were formed. To investigate the possible role of these biomolecules in this green synthetic process, Fourier-transformed infrared spectroscopy analysis was performed before and after the synthesis of nanoparticles. Furthermore, the carbohydrate composition was examined along with other variations observed after the synthesis of nanoparticles by size-exclusion chromatography. The study of the changes observed indicated that the polysaccharide fraction of the extract plays a role in the formation of the nanoparticles as well as in their stabilization. The in vitro antioxidant activity was analyzed by the determination of the reducing power, total content of phenolic compounds and the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) scavenging activity. Lastly, the antibacterial activity was tested against three types of bacteria with different cell wall composition. In particular, Ag@SM showed good inhibitory capacity on Gram+, especially onStaphylococcus aureuswith a MIC of 3.38 mu g/mL. [GRAPHICS] .
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