期刊
MATERIALS TODAY ADVANCES
卷 7, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.mtadv.2020.100073
关键词
Fluorescence enhancement; Nanostructures; Biosensing; Bioimaging; NIR window
资金
- EPSRC Centre for Doctoral Training in Advanced Characterisation of Materials [EP/L015277/1]
- EPSRC DTP training grant [EP/N509486/1]
- British Council Newton Grant [216239013]
- EPSRC [EP/S019367/1, EP/P02520X/1] Funding Source: UKRI
This review examines metal enhanced fluorescence (MEF) using gold (Au) nanostructures, with a focus on biomedical applications of this phenomenon, namely fluorescence biosensing and imaging. The mechanism by which MEF occurs will be briefly discussed before a thorough review of recent investigations, particularly surrounding cancer detection and imaging. Work in this field has primarily focused on substrate-based MEF and more recently has explored solution-based enhancement. Therefore, this review will examine both the different nanostructured substrates as well as the colloidal nanomaterials that have been synthesized, along with their interactions with fluorescent molecules. The potential applications of plasmonic probes for optical imaging, particularly in the near-infrared II (NIR-II) window, are also discussed. By incorporating MEF into diagnostic and imaging techniques, it is expected that there will be dramatic improvements to patient survival rates via early diagnosis and efficient treatment. (C) 2020 The Authors. Published by Elsevier Ltd.
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