期刊
INFLAMMATORY BOWEL DISEASES
卷 23, 期 4, 页码 561-569出版社
OXFORD UNIV PRESS INC
DOI: 10.1097/MIB.0000000000001064
关键词
methotrexate; male fertility; pregnancy outcome; paternal exposure; IBD
资金
- International Organization for the study of Inflammatory Bowel Disease (IOIBD)
- A.P. Moeller Foundation of the Advancement of Medical Science
- Digestive Health Foundation
- Graduate School of Health at Aarhus University, Denmark
Background: Inflammatory bowel disease incidence peaks during the reproductive years. Methotrexate (MTX) is frequently used for inflammatory bowel disease, but its use during pregnancy is contraindicated in women because of teratogenic effects. The aim of this review is to investigate the influence of MTX on male fertility and pregnancy outcomes after paternal MTX exposure. Methods: A systematic literature search was performed by applying 2 focus areas, methotrexate and male fertility or pregnancy outcome. Terms and keywords were used both as MeSH terms and free-text searches. Pertinent articles were searched for additional relevant references. Results: In animal studies, MTX induces aberrations in sperm DNA that have not been identified in humans. The effects of MTX on human sperm quality have only been described in case reports. A transient adverse effect on sperm quality with low-dose MTX has been reported, but several other cases have not found harmful effects of MTX. MTX has not been measured in human sperm ejaculates; yet, the risk of a direct toxic effect on the fetus through MTX-contaminated seminal plasma seems negligible. Until now, 284 pregnancies with paternal MTX exposure have been reported. The outcomes were 248 live births and a total of 13 malformations, with no overt indication of MTX embryopathy. Conclusions: This review reveals the lack of studies on the safety of MTX with regard to male reproduction. It is not clear whether MTX transiently influences male fertility and sperm DNA integrity, and more studies are needed. Comparative cohort studies found no increased risk of adverse pregnancy outcomes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据