A new nanometrological strategy for titanium dioxide nanoparticles screening and confirmation in personal care products by CE-spICP-MS

A new nanometrological approach was developed for screening of titania nanoparticles by capillary electrophoresis after adsorption of a target analyte namely L-cysteine onto the nanoparticles in a sodium phosphate buffer, followed by titanium elemental analysis by means of inductively-coupled plasma-mass spectrometry and size distribution measurements by single-particle mode. This analytical strategy involved a first screening of nanotitania in actual samples by electrophoresis, sensitivity being enhanced by cysteine which acts as a nanoparticles stabiliser. Detection and quantitation limits were 0.31 ng mu L-1 and 1.03 ng mu L-1 respectively for anatase nanoparticles in capillary electrophoresis, and a high amount of titanium was found in the samples subject to study (lip balm and two types of toothpaste) by total elemental analysis. Besides, the potential of single-particle modality for inductively-coupled plasma-mass spectrometry was exploited for a verification of particle size distribution, then confirming the presence of titanium dioxide nanoparticles as an ingredient in the composition of the real samples and validating the overall strategy herein presented.