期刊
HELIYON
卷 6, 期 8, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.heliyon.2020.e04793
关键词
Biomedical engineering; Microbial biotechnology; Protein engineering; Peptides; Virology; Molecular biology; Drug screen; SARS-Cov-2; -1 ribosomal frameshifting
资金
- Ministry of Science and Technology of the People's Republic of China [2018YFC1003502]
- West China Hospital, Sichuan University [Z20192008]
The -1 ribosomal frameshifting is vital for the translation of the open reading frame (ORF)1b in SARS-CoV-2. The products of ORF1b participate in viral replication. Therefore, changing the frameshift frequency reduces the survival of the virus. This study aimed to successfully develop a toolkit for screening antiviral drugs. Finally, the FDA-approved drug library was screened, revealing that ivacaftor and (-)-Huperzine A worked well in changing the -1 ribosomal frameshifting of SARS-CoV-2 in vitro.
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